PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function
Polycomb repressive complex 2 (PRC2) is MAX PROTECTION DEODORANT WILD a multisubunit histone-modifying enzyme complex that mediates methylation of histone H3 lysine 27 (H3K27).Trimethylated H3K27 (H3K27me3) is an epigenetic hallmark of gene silencing.PRC2 plays a crucial role in a plethora of fundamental biological processes, and PRC2 dysregulation